PAD Foundation

The aim of the PAD Foundation, a non-profit organization, thanks to the so‑called “5 x 1000” devolutions, is to organize, promote and fund, specialization courses, internships residentship for specialists, scientific studies and educational activities aimed at teaching the most advanced techniques for revascularization of the lower limbs in diabetic patients, thereby avoiding amputation and consequent disability.

Almost thirty years ago the experience of Dr. Graziani in non-surgical treatment of peripheral arterial disease (PAD) in diabetics started, because of their very high lower limb amputation risk. There were many difficulties to overcome at that time, not to mention the medical culture that believed this treatment to be impossible if not counterproductive. In other words, the innovation was consisting of extending the revascularization to the leg and foot arteries, adopting innovative modified-tailored coronary CTO recanalization techniques.
Instead in the last fifteen years these techniques have become very popular throughout the medical world, determining for the first time and in Italy, a significant reduction in the incidence of major amputations. Today talking about angioplasty and peripheral revascularization in diabetics is common, often representing the main attraction in conferences in both Italian and international medical conferences on the complications of diabetes and beyond.
How and perhaps more than any other techniques of the modern medical science, it is necessary from an institutional side, a special effort in order to favor these techniques’ teaching to medical specialists involved, such as cardiologists, radiologists or vascular surgeons.
These techniques are in fact more complex than other similar we currently adopt in the coronary tree, requiring a specifically designed training course in teaching centers of proved excellence. For that purpose the PAD Foundation, a non-profit institution, was recently established, with the specific task of promoting the reduction of major lower amputations in people with diabetes through research and the support of medical specialists for learning the new revascularization techniques.

In February 2012 the PAD Foundation was conferred the status of non-profit organization (ONLUS) by the Regional Revenue Agency of Lombardy and on 27 August 2012 a resolution of the Regional Council established its legal status.

The PAD Foundation is enrolled in the national register of non-profit organizations (ONLUS)

The board of directors:
Dott. Lanfroi Graziani
Chairman and founder

Projects and Plans

Website portal to favors scientific information and progress made using this technique.

Interactive multimedia contacts will be favored among interested specialists around the world, including organizing meetings and workshops.

Launch of educational campaign for the secondary prevention of vascular diabetes’s complications.
Our Results

Graziani L.: Crossing the Rubicon: A Closer Look at the Pedal Loop Technique. Ann Vasc Surg 2017;45:315–323

Graziani L.: Comprehensive Approach to Management of Critical Limb Ischemia. Curr Treat Options Cardio Med 2014; 16:332. New York, NY Springer Inc.

Graziani L, Jaff MR. Drug-eluting Balloons: Are These Failed Solutions for the Treatment of Below-the-knee Peripheral Artery Disease? Letter to the Editor. Ann Vasc Surg 2014;28:1078-1079

Graziani L.: Endovascular Interventions. A Case-Based Approach. Dieter, Robert S.; Dieter, Jr., Raymond A.; Dieter, III, Raymond A. (Eds.) Springer, 2014

Graziani L., Morelli L., Parini F., Franceschini L., Spano P., Calza S., Sigala S.: Clinical Outcome After Extended Endovascular Recanalization in Buerger's Disease in 20 Consecutive Cases. Ann Vasc Surg 2012;26:387-395.

Piaggesi A., Graziani L.: Integrated Management of the Ischemic Diabetic Foot. Diabetes Management 2011;1:53-65.

Graziani L., Morelli L.: Combined Retrograde–Antegrade Arterial Recanalization Through Collateral Vessels: Redefinition of the Technique for Below-the-Knee Arteries. Cardiovasc Intervent Radiol 2011;34(2):S78-S82.

Graziani L. Concerns on Article: The Impact of Isolated Tibial Disease on Outcomes in the Critical Limb Ischemic Population. (Ann Vasc Surg 2010;24:349-359). Ann Vasc Surg 2010; 24: 1156-1157.

Graziani L., Wallner H.: Tibioperoneal segment in: Schillinger M, Minar E Eds: Complex Cases in Peripheral Vascular Interventions. 2010 Informa UK Ltd, London, pagg. 220-238.

Graziani L., Piaggesi A.: Indications and Clinical Outcomes for Below Knee Endovascular Therapy: Review Article. Catheter Cardiovasc Intervent 2010;75:433–443.

Combined Retrograde–Antegrade External Iliac Artery Occlusion Recanalization Through Collaterals: Description of a New Technique. Cardiovasc Intervent Radiol. 2008 Sep;32:1097-100.

Graziani L.: Angioplastica nel paziente diabetico. G It Diabetol Metab 2008;28:147-153.

Silvestro A., Civelli P., Laffranchini G., Troianiello B., Graziani L.: Influence of anatomical factors on the feasibility and safety of carotid stenting in a series of 154 consecutive procedures. Journal of Cardiovascular Medicine. 2008;9:137-141.

Graziani L., Silvestro A., Monge L., et al: Transluminal angioplasty of peroneal artery branches in diabetics: initial technical experience. Cardiovasc Interv Radiol. 2008;31,49-55.

Minar E., Graziani L.: Complications in tibioperoaneal interventions, in: Shillinger M, Minar E Eds: Complications in Peripheral Vascular Interventions. 2007 Informa UK Ltd, London; p 201-207.

Graziani L., Silvestro A., Bertone V., Manara E., Alicandri A., Parrinello G., Manganoni A.: Percutaneous Transluminal Angioplasty is feasible and effective in patients on chronic dialysis with severe peripheral artery disease. Nephrol Dial Transplant. 2007;22:1144-1149.

Graziani L., Silvestro A., Bertone V., Manara E., Andreini R., Sigala A., Mingardi R., De Giglio R.: Vascular Involvement in Diabetic Subjects with Ischemic Foot Ulcer: A New Morphologic Categorization of Disease Severity. Eur J Vasc Endovasc Surg. 2007;33:453-460.

Graziani L., Silvestro A.: Alternative approaches in critical limb ischemia. London ,UK: Gosling ed.; 2006. Clinical Vision;17:2-7

Baumgartner I., Schainfeld R., Graziani L.: Management of peripheral vascular disease. Annual Review of Medicine. 2005;56:249-272.

Faglia E., Dalla Paola L., Clerici G., Clerissi J., Graziani L., Fusaro M., Gabrielli L., Losa S., Stella A., Gargiulo M., Mantero M., Caminiti M., Ninkovic S., Curci V., Morabito A.: Peripheral Angioplasty as the First-choice Revascularization Procedure in Diabetic Patients with Critical Limb Ischemia: Prospective Study of 993 Consecutive Patients Hospitalized and Followed Between 1999 and 2003. Eur J Vasc Endovasc Surg. 2005;29:620-627.

Faglia E., Mantero M., Caminiti M., Caravaggi C., De Giglio R., Pritelli C., Clerici G., Fratino P., De Cata P., Dalla Paola L., Mariani G., Poli M., Settembrini PG., Sciangula L., Morabito A., Graziani L.: Extensive use of peripheral angioplasty, particularly infrapopliteal, in the treatment of ischaemic diabetic foot ulcers: clinical results of a multicentric study of 221 consecutive diabetic subjects. Journal of Internal Medicine. 2002;252:225–232.

Inglese L., Graziani L., Tarricone R.: Il trattamento percutaneo delle arteriopatie ostruttive periferiche: i perché di una scelta. Ital Heart J Suppl 2000;1(9):1138-1147.


Support our Foundation